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About the Cover

Cover Figure


COVER The yellow area (left) shows a red-stained misfolded protein colocalizing with a green-stained molecular chaperone in the endoplasmic reticulum (ER) (image width, ~12 mm). After a shift from 39.5° to 32°C, the protein folds properly, passes quality control, leaves the ER, and enters vesiculotubular clusters (red spots on the right) en route to the cell surface. This special issue looks at quality control mechanisms in the cell, beginning on p. 1881 [Image: Anna Mezzacasa and Ari Helenius]

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Science. ISSN 0036-8075 (print), 1095-9203 (online)