Networks in Biology

Life and the Art of Networks

Barbara R. Jasny and L. Bryan Ray
Science 26 September 2003: 1863.
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Viewpoints

Molecular Networks: The Top-Down View

Dennis Bray
Science 26 September 2003: 1864-1865.
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Biological Networks: The Tinkerer as an Engineer

U. Alon
Science 26 September 2003: 1866-1867.
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Social Insect Networks

Jennifer H. Fewell
Science 26 September 2003: 1867-1870.
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Reviews

Communication in Neuronal Networks

Simon B. Laughlin and Terrence J. Sejnowski
Science 26 September 2003: 1870-1874.
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A Bacterial Cell-Cycle Regulatory Network Operating in Time and Space

Harley H. McAdams and Lucy Shapiro
Science 26 September 2003: 1874-1877.
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This Week in Science

Editor summaries of this week's papers.
Science 26 September 2003: 1809.
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Editorial:
Health Insurance in the USA

Julius B. Richmond and Rashi Fein
Science 26 September 2003: 1813.
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Editors' Choice

Highlights of the recent literature.
Science 26 September 2003: 1815.
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NetWatch

Best of the Web in science.
Science 26 September 2003: 1823.
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 AAAS News & Notes

Science 26 September 2003: 1861.

 NEW PRODUCTS

Science 26 September 2003: 1929.

News of the Week

SCIENTIFIC COMMUNITY:
Johns Hopkins Biodefense Pioneers Depart en Masse

Martin Enserink
Science 26 September 2003: 1824.
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INFECTIOUS DISEASES:
Singapore Lab Faulted in SARS Case

Martin Enserink
Science 26 September 2003: 1824.
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ARCHAEOLOGY:
Good and Bad News From Iraq

Andrew Lawler
Science 26 September 2003: 1825.
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INDIA:
Science Minister Resigns, Faces Rioting Charges

Pallava Bagla
Science 26 September 2003: 1825.
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MATERIALS SCIENCE:
Tiny Particles Flag Scarce Proteins

Robert F. Service
Science 26 September 2003: 1827.
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ECOLOGICAL NETWORKS:
Panel Suggests a Different Shade of NEON

Jocelyn Kaiser
Science 26 September 2003: 1828.
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INFECTIOUS DISEASES:
Gates Pledges $168 Million for Malaria Research

Martin Enserink
Science 26 September 2003: 1828.
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EARTH OBSERVATION:
Satellite Start-Up Offers Cut-Price Window on the World

Daniel Clery
Science 26 September 2003: 1829-1831.
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PLANETARY SCIENCE:
Finally, An End for Galileo

Richard A. Kerr
Science 26 September 2003: 1831.
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ScienceScope

Science 26 September 2003: 1827.
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Random Samples

Science 26 September 2003: 1842.
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News Focus

PLANETARY SCIENCE:
Putting Martian Science to the Test

Richard A. Kerr
Science 26 September 2003: 1832-1834.
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PLANETARY SCIENCE:
A-Roving We Will Go, Slowly

Richard A. Kerr
Science 26 September 2003: 1834.
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STEVE GOODMAN PROFILE:
Madagascar Tames the Bohemian of Biology

John Bohannon
Science 26 September 2003: 1835-1837.
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STEVE GOODMAN PROFILE:
A Biological Bible for Madagascar

John Bohannon
Science 26 September 2003: 1836.
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MEIOTIC DRIVE:
Bickering Genes Shape Evolution

Elizabeth Pennisi
Science 26 September 2003: 1837-1839.
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WILDLIFE BIOLOGY:
In Search of the Ivory Gull

Kevin Krajick
Science 26 September 2003: 1840-1841.
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Letters

This Week's Letters

Science 26 September 2003: 1845.
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 Hooked on Hooke

Martin E. Gordon
Science 26 September 2003: 1845.
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 Hooke and Generation of Molds

Antonio Lazcano
Science 26 September 2003: 1845.
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 Risks of Genetically Engineered Crops

Doug Gurian-Sherman; and Steven H. Strauss
Science 26 September 2003: 1845.
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 Good and Bad Amyloid Antibodies

Mark P. Mattson and Sic L. Chan
Science 26 September 2003: 1847-1849.
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 A Clarification on Data Availability

John J. Donohue
Science 26 September 2003: 1849.
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 CORRECTIONS AND CLARIFICATIONS

Science 26 September 2003: 1849.
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Books et al.

MICROBIOLOGY:
An Era's End and the Start of a New One?

David A. Hopwood
Science 26 September 2003: 1850-1851.
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 Browsings

Science 26 September 2003: 1850.
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PLANETARY SCIENCE:
Nota Bene: Cruising Mars with the Crater Guy

Linda Rowan
Science 26 September 2003: 1851.
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 Books Received

Science 26 September 2003: 1851.

Policy Forum

PUBLIC HEALTH:
Building Microbial Forensics as a Response to Bioterrorism

Bruce Budowle, Steven E. Schutzer, Anja Einseln, Lynda C. Kelley, Anne C. Walsh, Jenifer A. L. Smith, Babetta L. Marrone, James Robertson, and Joseph Campos
Science 26 September 2003: 1852-1853.
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Perspectives

GENOMICS:
A Dog's Breakfast?

Stephen J. O'Brien and William J. Murphy
Science 26 September 2003: 1854-1855.
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IMMUNOLOGY:
Giving Credit Where Credit Is Due

Natalya V. Serbina and Eric G. Pamer
Science 26 September 2003: 1856-1857.
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MATERIALS SCIENCE:
Modeling Strain Hardening the Hard Way

Peter Gumbsch
Science 26 September 2003: 1857-1858.
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OCEAN SCIENCE:
Enhanced: Internal Tides and Ocean Mixing

Chris Garrett
Science 26 September 2003: 1858-1859.
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CELL BIOLOGY:
An Age of Instability

David A. Sinclair
Science 26 September 2003: 1859-1860.
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Brevia

 A Synthesis of Sumanene, a Fullerene Fragment

Hidehiro Sakurai, Taro Daiko, and Toshikazu Hirao
Science 26 September 2003: 1878.
A bowl-shaped fragment of the C₆₀ cage, a pentagon surrounded by six hexagons, can be synthesized in just a few steps. Full Text »|   PDF »|   Supporting Online Material »|  

Reports

The Role of Collinear Interaction in Dislocation-Induced Hardening

R. Madec, B. Devincre, L. Kubin, T. Hoc, and D. Rodney
Science 26 September 2003: 1879-1882.
Simulations show that deformation hardens some metals by annihilation of parallel defects, not by the formation of immobile junctions between defects, as previously supposed. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

DNA-Templated Self-Assembly of Protein Arrays and Highly Conductive Nanowires

Hao Yan, Sung Ha Park, Gleb Finkelstein, John H. Reif, and Thomas H. LaBean
Science 26 September 2003: 1882-1884.
DNA tiles, each containing four arms, can be linked together to form a flexible template for growing other molecules, including long silver nanowires. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Nanoparticle-Based Bio-Bar Codes for the Ultrasensitive Detection of Proteins

Jwa-Min Nam, C. Shad Thaxton, and Chad A. Mirkin
Science 26 September 2003: 1884-1886.
Genetic probes using coated gold and magnetic particles can recognize and separate as few as 18 target molecules per sample. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Particle Formation by Ion Nucleation in the Upper Troposphere and Lower Stratosphere

S.-H. Lee, J. M. Reeves, J. C. Wilson, D. E. Hunton, A. A. Viggiano, T. M. Miller, J. O. Ballenthin, and L. R. Lait
Science 26 September 2003: 1886-1889.
Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Cyclic Variation and Solar Forcing of Holocene Climate in the Alaskan Subarctic

Feng Sheng Hu, Darrell Kaufman, Sumiko Yoneji, David Nelson, Aldo Shemesh, Yongsong Huang, Jian Tian, Gerard Bond, Benjamin Clegg, and Thomas Brown
Science 26 September 2003: 1890-1893.
Climate changes are coeval with changes in the abundance of cosmogenically produced isotopes in a record from an Alaskan lake, implying a solar influence on Holocene climate. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Intensive Pre-Incan Metallurgy Recorded by Lake Sediments from the Bolivian Andes

Mark B. Abbott and Alexander P. Wolfe
Science 26 September 2003: 1893-1895.
Metal accumulation in lake sediments near a huge silver deposit in South America records mining and smelting during Inca and Spanish times and indicates an earlier industry at around 1000 A.D. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Inactivation of TNF Signaling by Rationally Designed Dominant-Negative TNF Variants

Paul M. Steed, Malú G. Tansey, Jonathan Zalevsky, Eugene A. Zhukovsky, John R. Desjarlais, David E. Szymkowski, Christina Abbott, David Carmichael, Cheryl Chan, Lisa Cherry, Peter Cheung, Arthur J. Chirino, Hyo H. Chung, Stephen K. Doberstein, Araz Eivazi, Anton V. Filikov, Sarah X. Gao, René S. Hubert, Marian Hwang, Linus Hyun, Sandhya Kashi, Alice Kim, Esther Kim, James Kung, Sabrina P. Martinez, Umesh S. Muchhal, Duc-Hanh T. Nguyen, Christopher O'Brien, Donald O'Keefe, Karen Singer, Omid Vafa, Jost Vielmetter, Sean C. Yoder, and Bassil I. Dahiyat
Science 26 September 2003: 1895-1898.
A designed variant of a peptide that activates inflammation binds to and sequesters the normal form of the peptide, raising a possible approach to treatment. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

The Dog Genome: Survey Sequencing and Comparative Analysis

Ewen F. Kirkness, Vineet Bafna, Aaron L. Halpern, Samuel Levy, Karin Remington, Douglas B. Rusch, Arthur L. Delcher, Mihai Pop, Wei Wang, Claire M. Fraser, and J. Craig Venter
Science 26 September 2003: 1898-1903.
A low-coverage sequence of the dog genome, enhanced with information from the genomes of other mammals, yields numerous homologies with human genes. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Reprogramming Control of an Allosteric Signaling Switch Through Modular Recombination

John E. Dueber, Brian J. Yeh, Kayam Chak, and Wendell A. Lim
Science 26 September 2003: 1904-1908.
A nodal enzyme in a cellular signaling network possesses domains that may be interchanged to produce a functional protein with new regulatory properties. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

An Age-Induced Switch to a Hyper-Recombinational State

Michael A. McMurray and Daniel E. Gottschling
Science 26 September 2003: 1908-1911.
The daughters of aging yeast mother cells increasingly lose bits of their chromosomes, whereas the mother cells' genomes remain largely intact. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Essential Roles for Ecdysone Signaling During Drosophila Mid-Embryonic Development

Tatiana Kozlova and Carl S. Thummel
Science 26 September 2003: 1911-1914.
Published online 4 September 2003 [DOI: 10.1126/science.1087419] (in Science Express Reports)
In insects, the steroid hormone ecdysone, which triggers the dramatic metamorphosis from larva to adult, also controls major changes in body shape during embryonic development. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Sequence-Dependent Pausing of Single Lambda Exonuclease Molecules

Thomas T. Perkins, Ravindra V. Dalal, Paul G. Mitsis, and Steven M. Block
Science 26 September 2003: 1914-1918.
Published online 28 August 2003 [DOI: 10.1126/science.1088047] (in Science Express Reports)
An enzyme can digest several thousand nucleotides of one strand of a DNA helix through movement at a constant rate, interspersed with pauses at certain sequences. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Salmonella SipA Polymerizes Actin by Stapling Filaments with Nonglobular Protein Arms

Mirjana Lilic, Vitold E. Galkin, Albina Orlova, Margaret S. VanLoock, Edward H. Egelman, and C. Erec Stebbins
Science 26 September 2003: 1918-1921.
Upon infection, Salmonella injects a protein with two arms that bind and polymerize actin filaments in the cellular host, thus facilitating its own uptake. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

R2D2, a Bridge Between the Initiation and Effector Steps of the Drosophila RNAi Pathway

Qinghua Liu, Tim A. Rand, Savitha Kalidas, Fenghe Du, Hyun-Eui Kim, Dean P. Smith, and Xiaodong Wang
Science 26 September 2003: 1921-1925.
A newly described protein links the generation of small RNAi's with their ability to destroy their target RNA and so inhibit expression of the encoded protein. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Epidermal Viral Immunity Induced by CD8⁺ Dendritic Cells But Not by Langerhans Cells

Rhys S. Allan, Chris M. Smith, Gabrielle T. Belz, Allison L. van Lint, Linda M. Wakim, William R. Heath, and Francis R. Carbone
Science 26 September 2003: 1925-1928.
Viruses infecting the skin trigger an immune response in an unexpected dendritic cell subset-not, as previously thought, in Langerhans cells. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|