This Week in Science

Editor summaries of this week's papers.
Science 10 October 2003: 193.
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Editorial:
Johannesburg + 1: S&T Challenges

Shirley Malcom
Science 10 October 2003: 197.
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Editors' Choice

Highlights of the recent literature.
Science 10 October 2003: 199.
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NetWatch

Best of the Web in science.
Science 10 October 2003: 205.
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 Quarterly Author Index

Science 10 October 2003: 1-12.

 NEW PRODUCTS

Science 10 October 2003: 300.

 Gordon Research Conferences

Science 10 October 2003: 301-307.

News of the Week

INFECTIOUS DISEASES:
New Biodefense Splurge Creates Hotbeds, Shatters Dreams

Martin Enserink
Science 10 October 2003: 206-207.
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RESEARCH OVERSIGHT:
Panel Seeks to Balance Science and Security

Martin Enserink
Science 10 October 2003: 206.
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RUSSIA'S NUCLEAR CITIES:
Swords-to-Plowshares Program Suffers Meltdown

Paul Webster
Science 10 October 2003: 207.
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COSMOLOGY:
Polyhedral Model Gives the Universe An Unexpected Twist

Charles Seife
Science 10 October 2003: 209-20.
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CLIMATE CHANGE:
Warming Indian Ocean Wringing Moisture From the Sahel

Richard A. Kerr
Science 10 October 2003: 210-211.
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SCIENTIFIC PUBLISHING:
U.S. License Needed to Edit Iranian Papers

Yudhijit Bhattacharjee
Science 10 October 2003: 210.
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BIOTECHNOLOGY:
The Ultimate Gene Gizmo: Humanity on a Chip

Elizabeth Pennisi
Science 10 October 2003: 211.
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INFECTIOUS DISEASES:
SARS Researchers Report New Animal Models

Martin Enserink
Science 10 October 2003: 213.
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DEEP-SEA DRILLING:
Same Crew to Run New Program

Richard A. Kerr
Science 10 October 2003: 213.
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ScienceScope

Science 10 October 2003: 209.
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Random Samples

Science 10 October 2003: 224.
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News Focus

CELL BIOLOGY:
How Cells Step Out

Jean Marx
Science 10 October 2003: 214-216.
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YOSHIHIDE HAYASHIZAKI PROFILE:
He's Writing the Book on the Mouse Genome

Dennis Normile
Science 10 October 2003: 217-218.
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MOLECULAR MEDICINE:
NIH Dives Into Drug Discovery

Jennifer Couzin
Science 10 October 2003: 218-221.
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ECOLOGY:
Freshwater Eels Are Slip-Sliding Away

Richard Stone
Science 10 October 2003: 221-222.
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INFECTIOUS DISEASES:
An Obscure Weapon of the Cold War Edges Into the Limelight

Gretchen Vogel
Science 10 October 2003: 222-223.
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Letters

This Week's Letters

Science 10 October 2003: 226-229.
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 Assessing the Future Hydrogen Economy

Daniel M. Kammen, Timothy E. Lipman;, Amory B. Lovins;, Peter A. Lehman;, John M. Eiler, Tracey K. Tromp, Run-Lie Shia, Mark Allen, and Y. L. Yung
Science 10 October 2003: 226-229.
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Books et al.

ECOLOGY:
Reflections on Lizard Diversity

Martin J. Whiting
Science 10 October 2003: 230-231.
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MOLECULAR BIOLOGY:
Impressions of Watson Through 50 Years

D. E. Koshland Jr.
Science 10 October 2003: 231.
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 Books Received

Science 10 October 2003: 231.

Essays on Science and Society

PERCEPTIONS OF SCIENCE:
The Anatomical Mission to Burma

Michael Sappol
Science 10 October 2003: 232-233.
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Perspectives

CIRCADIAN RHYTHMS: Liver Regeneration Clocks On

Ueli Schibler
Science 10 October 2003: 234-235.
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CHEMISTRY:
Enhanced: A View of Unusual Peroxides

Alexander Greer
Science 10 October 2003: 235-236.
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ATMOSPHERIC SCIENCE:
Ozone and Climate Change

David J. Karoly
Science 10 October 2003: 236-237.
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NEUROSCIENCE:
Feeling the Pain of Social Loss

Jaak Panksepp
Science 10 October 2003: 237-239.
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CHEMISTRY:
The Motions of an Enzyme Soloist

Michel Orrit
Science 10 October 2003: 239-240.
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GENOMICS:
Microarrays--Guilt by Association

John Quackenbush
Science 10 October 2003: 240-241.
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DEVELOPMENTAL BIOLOGY:
Rocks That Roll Zebrafish

Donna M. Fekete
Science 10 October 2003: 241-242.
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Review

The Elusive Bose Metal

Philip Phillips and Denis Dalidovich
Science 10 October 2003: 243-247.
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Brevia

 Structure of West Nile Virus

Suchetana Mukhopadhyay, Bong-Suk Kim, Paul R. Chipman, Michael G. Rossmann, and Richard J. Kuhn
Science 10 October 2003: 248.
A 17 Å structure for West Nile virus reveals a multilayered, 500 Å structure, with an outer shell of two transmembrane proteins. Full Text »|   PDF »|   Supporting Online Material »|  

Research Articles

A Gene-Coexpression Network for Global Discovery of Conserved Genetic Modules

Joshua M. Stuart, Eran Segal, Daphne Koller, and Stuart K. Kim
Science 10 October 2003: 249-255.
Published online 21 August 2003 [DOI: 10.1126/science.1087447] (in Science Express Research Articles)
Twenty-two thousand pairs of genes that are coexpressed in organisms as diverse as yeast, flies, worms, and humans are used to construct a genetic network and predict the functions of proteins. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Control Mechanism of the Circadian Clock for Timing of Cell Division in Vivo

Takuya Matsuo, Shun Yamaguchi, Shigeru Mitsui, Aki Emi, Fukuko Shimoda, and Hitoshi Okamura
Science 10 October 2003: 255-259.
Published online 21 August 2003 [DOI: 10.1126/science.1086271] (in Science Express Research Articles)
The circadian clock controls the time at which cells divide by directly regulating the expression of genes involved in mitosis. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Reports

Phosphadioxirane: A Peroxide from an Ortho-Substituted Arylphosphine and Singlet Dioxygen

David G. Ho, Ruomei Gao, Jeff Celaje, Ha-Yong Chung, and Matthias Selke
Science 10 October 2003: 259-262.
Adding bulky substitutes to an organic molecule allowed detailed NMR observation of its rapid oxidation, a reaction typical of many industrial applications. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Protein Conformational Dynamics Probed by Single-Molecule Electron Transfer

Haw Yang, Guobin Luo, Pallop Karnchanaphanurach, Tai-Man Louie, Ivan Rech, Sergio Cova, Luying Xun, and X. Sunney Xie
Science 10 October 2003: 262-266.
Rapid temporal analysis of a single enzyme molecule's fluorescence indicates that the protein can switch among several conformations within milliseconds. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Periodic Mesoporous Organosilicas Containing Interconnected [Si(CH₂)]₃ Rings

Kai Landskron, Benjamin D. Hatton, Doug D. Perovic, and Geoffrey A. Ozin
Science 10 October 2003: 266-269.
Nanocomposite materials composed of three-ring silica-methylene building blocks contain large pores and have properties conducive for microelectronic applications. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Global Warming Trend of Mean Tropospheric Temperature Observed by Satellites

Konstantin Y. Vinnikov and Norman C. Grody
Science 10 October 2003: 269-272.
Published online 11 September 2003 [DOI: 10.1126/science.1087910] (in Science Express Reports)
A reanalysis of satellite measurements of temperature since 1978 that account for the daily cycle shows that global air temperatures have warmed at a rate consistent with surface temperature trends and climate models. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Simulation of Recent Southern Hemisphere Climate Change

Nathan P. Gillett and David W. J. Thompson
Science 10 October 2003: 273-275.
Climate model simulations show that recent stratospheric ozone loss above Antarctica has affected that region's climate near Earth's surface. Abstract »|   Full Text »|   PDF »|  

Isolation and Characterization of Viruses Related to the SARS Coronavirus from Animals in Southern China

Y. Guan, B. J. Zheng, Y. Q. He, X. L. Liu, Z. X. Zhuang, C. L. Cheung, S. W. Luo, P. H. Li, L. J. Zhang, Y. J. Guan, K. M. Butt, K. L. Wong, K. W. Chan, W. Lim, K. F. Shortridge, K. Y. Yuen, J. S. M. Peiris, and L. L. M. Poon
Science 10 October 2003: 276-278.
Published online 4 September 2003 [DOI: 10.1126/science.1087139] (in Science Express Reports)
Civet cats, a raccoon dog, and a ferret badger in an animal market in Gunagdong, China, were infected with a coronavirus identical to the one that causes SARS in humans save for an extra 29-nucleotide sequence. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

The Prp19p-Associated Complex in Spliceosome Activation

Shih-Peng Chan, Der-I Kao, Wei-Yü Tsai, and Soo-Chen Cheng
Science 10 October 2003: 279-282.
Published online 11 September 2003 [DOI: 10.1126/science.1086602] (in Science Express Reports)
A particular complex of proteins catalyzes the reorganization of the spliceosome to allow it to identify and remove non-protein coding regions in the assembly of messenger RNA. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Control of Crystal Size and Lattice Formation by Starmaker in Otolith Biomineralization

Christian Söllner, Manfred Burghammer, Elisabeth Busch-Nentwich, Jürgen Berger, Heinz Schwarz, Christian Riekel, and Teresa Nicolson
Science 10 October 2003: 282-286.
A protein directs the growth of the round calcium carbonate crystals in the fish ear that are required for maintaining equilibrium; without it, the crystals are star-shaped and the fish are disoriented. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

A Functional Link Between RuBisCO-like Protein of Bacillus and Photosynthetic RuBisCO

Hiroki Ashida, Yohtaro Saito, Chojiro Kojima, Kazuo Kobayashi, Naotake Ogasawara, and Akiho Yokota
Science 10 October 2003: 286-290.
The photosynthetic enzyme that converts carbon dioxide into organic carbon may be derived from a similar enzyme that processes methionine in nonphotosynthetic bacteria or archea. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Does Rejection Hurt? An fMRI Study of Social Exclusion

Naomi I. Eisenberger, Matthew D. Lieberman, and Kipling D. Williams
Science 10 October 2003: 290-292.
Rejection by other people in a social situation triggers brain activity resembling that produced by physical pain. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

A Neurexin-Related Protein, BAM-2, Terminates Axonal Branches in C. elegans

Antonio Colavita and Marc Tessier-Lavigne
Science 10 October 2003: 293-296.
A membrane protein acts as a stop signal for developing neurons, preventing them from overshooting their target sites. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Gene Expression Profiles in the Brain Predict Behavior in Individual Honey Bees

Charles W. Whitfield, Anne-Marie Cziko, and Gene E. Robinson
Science 10 October 2003: 296-299.
Patterns of gene expression in brains of single nursing bees differ predictably from those of foraging bees. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|