Genes in Action

Solving Gene Expression

Barbara R. Jasny and Leslie Roberts
Science 22 October 2004: 629.
Summary »|   PDF »|  

News

Getting the Noise Out of Gene Arrays

Eliot Marshall
Science 22 October 2004: 630-631.
Summary »|   Full Text »|   PDF »|  

Searching for the Genome's Second Code

Elizabeth Pennisi
Science 22 October 2004: 632-635.
Summary »|   Full Text »|   PDF »|  

A Fast and Furious Hunt for Gene Regulators

Elizabeth Pennisi
Science 22 October 2004: 635.
Summary »|   Full Text »|   PDF »|  

Viewpoints

The ENCODE (ENCyclopedia Of DNA Elements) Project

The ENCODE Project Consortium
Science 22 October 2004: 636-640.
Abstract »|   Full Text »|   PDF »|   Affiliations for ENCODE Consortium Members »|  Supporting Online Material »|  

Systems Biology and New Technologies Enable Predictive and Preventative Medicine

Leroy Hood, James R. Heath, Michael E. Phelps, and Biaoyang Lin
Science 22 October 2004: 640-643.
Abstract »|   Full Text »|   PDF »|  

Gene Order and Dynamic Domains

Steven T. Kosak and Mark Groudine
Science 22 October 2004: 644-647.
Abstract »|   Full Text »|   PDF »|  

Review

Cis-Acting Regulatory Variation in the Human Genome

Tomi Pastinen and Thomas J. Hudson
Science 22 October 2004: 647-650.
Abstract »|   Full Text »|   PDF »|  

This Week in Science

Editor summaries of this week's papers.
Science 22 October 2004: 571.
|Full Text »

Editorial:
Genomics and Drug Toxicity

Peter G. Lord and Thomas Papoian
Science 22 October 2004: 575.
Summary »|   PDF »|  

Editors' Choice

Highlights of the recent literature.
Science 22 October 2004: 577.
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NetWatch

Best of the Web in science.
Science 22 October 2004: 585.
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 New Products

Science 22 October 2004: 709.
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News of the Week

BIOETHICS:
Stem Cell Researchers Mull Ideas for Self-Regulation

Constance Holden
Science 22 October 2004: 586.
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MALARIA:
A Complex New Vaccine Shows Promise

Gretchen Vogel
Science 22 October 2004: 587-589.
Summary »|   Full Text »|   PDF »|  

PLANETARY SCIENCE:
Flipped Switch Sealed the Fate of Genesis Spacecraft

Richard A. Kerr
Science 22 October 2004: 587.
Summary »|   Full Text »|   PDF »|  

CANADA:
Martin Backs Science Academy

Wayne Kondro
Science 22 October 2004: 589.
Summary »|   Full Text »|   PDF »|  

BIOTERRORISM AND THE COURTS:
Butler Appeals Conviction, Risking Longer Sentence

David Malakoff
Science 22 October 2004: 590.
Summary »|   Full Text »|   PDF »|  

INFECTIOUS DISEASES:
Bird Flu Infected 1000, Dutch Researchers Say

Martin Enserink
Science 22 October 2004: 590.
Summary »|   Full Text »|   PDF »|  

BIOCONTAINMENT:
1918 Flu Experiments Spark Concerns About Biosafety

Jocelyn Kaiser
Science 22 October 2004: 591.
Summary »|   Full Text »|   PDF »|  

GENERAL RELATIVITY:
Swiveling Satellites See Earth's Relativistic Wake

Charles Seife
Science 22 October 2004: 592.
Summary »|   Full Text »|   PDF »|  

MEDICINE:
Metabolic Defects Tied to Mitochondrial Gene

Jean Marx
Science 22 October 2004: 592-593.
Summary »|   Full Text »|   PDF »|  

PHYSICS:
Researchers Build Quantum Info Bank By Writing on the Clouds

Charles Seife
Science 22 October 2004: 593.
Summary »|   Full Text »|   PDF »|  

NATIONAL INSTITUTES OF HEALTH:
Male Sweep of New Award Raises Questions of Bias

Jeffrey Mervis
Science 22 October 2004: 595.
Summary »|   Full Text »|   PDF »|  

NATIONAL SCIENCE FOUNDATION:
End of Cost Sharing Could Boost Competition

Jeffrey Mervis
Science 22 October 2004: 595.
Summary »|   Full Text »|   PDF »|  

ScienceScope

Science 22 October 2004: 589.
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Random Samples

Science 22 October 2004: 605.
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News Focus

IMMUNOLOGY:
Policing the Immune System

Ingrid Wickelgren
Science 22 October 2004: 596-599.
Summary »|   Full Text »|   PDF »|  

CLIMATE CHANGE:
A Few Good Climate Shifters

Richard A. Kerr
Science 22 October 2004: 599-601.
Summary »|   Full Text »|   PDF »|  

BEHAVIORAL SCIENCE:
NIMH Takes a New Tack, Upsetting Behavioral Researchers

Constance Holden
Science 22 October 2004: 602.
Summary »|   Full Text »|   PDF »|  

INFECTIOUS DISEASES:
Hawaii Girds Itself for Arrival of West Nile Virus

Erik Stokstad
Science 22 October 2004: 603.
Summary »|   Full Text »|   PDF »|  

Letters

This Week's Letters

Science 22 October 2004: 609.
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 Another Question for Bush and Kerry

Sol Michael Gruner
Science 22 October 2004: 609.
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 Struggling to Attend U.S. Meetings

Boyan K. Garvalov
Science 22 October 2004: 609.
Full Text »|   PDF »|  

 Is Bedout an Impact Crater? Take 1

Paul Wignall, Bruce Thomas, Robbert Willink, John Watling;, Becker, R. J. Poreda, and K. O. Pope
Science 22 October 2004: 609-610.
Full Text »|   PDF »|  

 Is Bedout an Impact Crater? Take 2

Paul R. Renne, H. Jay Melosh, Kenneth A. Farley, W. Uwe Reimold, Christian Koeberl, Michael R. Rampino, Simon P. Kelly, Boris A. Ivanov;, L. Becker, R. J. Poreda, A. R. Basu, K. O. Pope, T. M. Harrison, C. Nicholson, and R. Iasky
Science 22 October 2004: 610-612.
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 The Next Step for Kennewick Man

Francis P. McManamon
Science 22 October 2004: 612-613.
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 CORRECTIONS AND CLARIFICATIONS

Science 22 October 2004: 613.
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 Protein Design: Quo Vadis?

Gert Vriend
Science 12 November 2004: 1135.
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Books et al.

PHILOSOPHY OF BIOLOGY:
A Centenarian's Summary

Matthias Glaubrecht
Science 22 October 2004: 614-615.
Summary »|   Full Text »|   PDF »|  

FICTION:
Of Politics and Particle Physics

Jay M. Pasachoff
Science 22 October 2004: 615.
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 Books Received

Science 22 October 2004: 615.

Policy Forum

NUCLEAR SAFETY:
Brazil's Nuclear Puzzle

Liz Palmer and Gary Milhollin
Science 22 October 2004: 617.
Summary »|   Full Text »|   PDF »|  

Perspectives

CHEMISTRY:
A Fresh Look at Electron Hydration

Kenneth D. Jordan
Science 22 October 2004: 618-619.
Summary »|   Full Text »|   PDF »|  

GENETICS:
The Critical Region in Trisomy 21

David L. Nelson and Richard A. Gibbs
Science 22 October 2004: 619-621.
Summary »|   Full Text »|   PDF »|  

CLIMATE:
The Real Color of Climate Change?

Timothy J. Osborn and Keith R. Briffa
Science 22 October 2004: 621-622.
Published online 30 September 2004 [DOI: 10.1126/science.1104416] (in Science Express Perspectives)
Summary »|   Full Text »|   PDF »|  

PLANT BIOLOGY:
A Plant ABC Transporter Takes the Lotus Seat

Burkhard Schulz and Wolf B. Frommer
Science 22 October 2004: 622-625.
Summary »|   Full Text »|   PDF »|  

CHEMISTRY:
Enhanced: Redesigning Genetics

Steven A. Benner
Science 22 October 2004: 625-626.
Summary »|   Full Text »|   PDF »|  

Brevia

A Precocial Avian Embryo from the Lower Cretaceous of China

Zhonghe Zhou and Fucheng Zhang
Science 22 October 2004: 653.
The large skull, feathers, and ossified skeleton of an Early Cretaceous bird embryo from China suggest that early birds could move around on their own after hatching. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Research Article

A Gene Expression Map for the Euchromatic Genome of Drosophila melanogaster

Viktor Stolc, Zareen Gauhar, Christopher Mason, Gabor Halasz, Marinus F. van Batenburg, Scott A. Rifkin, Sujun Hua, Tine Herreman, Waraporn Tongprasit, Paolo Emilio Barbano, Harmen J. Bussemaker, and Kevin P. White
Science 22 October 2004: 655-660.
Measurement of gene expression during development from the entire Drosophila genome reveals an unexpectedly large number of new spliced RNAs and noncoding RNAs. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Reports

Quantum-to-Classical Transition with Single-Photon-Added Coherent States of Light

Alessandro Zavatta, Silvia Viciani, and Marco Bellini
Science 22 October 2004: 660-662.
Adding one photon at a time produces a smooth transition between quantum and classical light through a new nonclassical state containing a few coherent photons. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Quantum State Transfer Between Matter and Light

D. N. Matsukevich and A. Kuzmich
Science 22 October 2004: 663-666.
Single photons can be stored and retrieved in a cloud of cold rubidium atoms, a process that can be used to encode information. Abstract »|   Full Text »|   PDF »|  

Electric Field Effect in Atomically Thin Carbon Films

K. S. Novoselov, A. K. Geim, S. V. Morozov, D. Jiang, Y. Zhang, S. V. Dubonos, I. V. Grigorieva, and A. A. Firsov
Science 22 October 2004: 666-669.
Exfoliating graphite yields stable carbon films just a few atoms thick, which on a silicon substrate act as a new type of strong semimetal transistor. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Hydrated Electron Dynamics: From Clusters to Bulk

A. E. Bragg, J. R. R. Verlet, A. Kammrath, O. Cheshnovsky, and D. M. Neumark
Science 22 October 2004: 669-671.
Published online 16 September 2004 [DOI: 10.1126/science.1103527] (in Science Express Reports)
Photoelectron spectroscopy reveals that an excited electron in a water cluster relaxes rapidly and then transfers energy to surrounding water molecules, disrupting their hydrogen bonding. Abstract »|   Full Text »|   PDF »|  

Electrons in Finite-Sized Water Cavities: Hydration Dynamics Observed in Real Time

D. Hern Paik, I-Ren Lee, Ding-Shyue Yang, J. Spencer Baskin, and Ahmed H. Zewail
Science 22 October 2004: 672-675.
Published online 16 September 2004 [DOI: 10.1126/science.1102827] (in Science Express Reports)
Photoelectron spectroscopy reveals that an excited electron in a water cluster relaxes rapidly and then transfers energy to surrounding water molecules, disrupting their hydrogen bonding. Abstract »|   Full Text »|   PDF »|  

How Do Small Water Clusters Bind an Excess Electron?

Nathan I. Hammer, Joong-Won Shin, Jeffrey M. Headrick, Eric G. Diken, Joseph R. Roscioli, Gary H. Weddle, and Mark A. Johnson
Science 22 October 2004: 675-679.
Published online 16 September 2004 [DOI: 10.1126/science.1102792] (in Science Express Reports)
An excess electron in a small water cluster mainly resides with a water molecule that accepts hydrogen bonds from two others, resolving a long-standing question. Abstract »|   Full Text »|   PDF »|  

Reconstructing Past Climate from Noisy Data

Hans von Storch, Eduardo Zorita, Julie M. Jones, Yegor Dimitriev, Fidel González-Rouco, and Simon F. B. Tett
Science 22 October 2004: 679-682.
Published online 30 September 2004 [DOI: 10.1126/science.1096109] (in Science Express Reports)
The climate of past centuries was more variable than is represented in regression-based reconstructions that use noisy data from climate indicators such as tree rings. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Mycobacterial Ku and Ligase Proteins Constitute a Two-Component NHEJ Repair Machine

Marina Della, Phillip L. Palmbos, Hui-Min Tseng, Louise M. Tonkin, James M. Daley, Leana M. Topper, Robert S. Pitcher, Alan E. Tomkinson, Thomas E. Wilson, and Aidan J. Doherty
Science 22 October 2004: 683-685.
Prokaryotes can repair a double-stranded break in DNA with just one multipurpose and one joining enzyme, whereas mammals require numerous enzymes. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Elemental and Redox Analysis of Single Bacterial Cells by X-ray Microbeam Analysis

Kenneth M. Kemner, Shelly D. Kelly, Barry Lai, Joerg Maser, Edward J. O'Loughlin, Deirdre Sholto-Douglas, Zhonghou Cai, Mark A. Schneegurt, Charles F. Kulpa, Jr., and Kenneth H. Nealson
Science 22 October 2004: 686-687.
The distribution and oxidation state of chromium and other metals important in cell metabolism can be observed in single living cells with a high-energy x-ray beam. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

A Chromosome 21 Critical Region Does Not Cause Specific Down Syndrome Phenotypes

L. E. Olson, J. T. Richtsmeier, J. Leszl, and R. H. Reeves
Science 22 October 2004: 687-690.
In a mouse version of Down syndrome, the so-called Down syndrome critical region unexpectedly fails to cause typical facial abnormalities, implying that other genes are involved. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

In Silico Genetics: Identification of a Functional Element Regulating H2-E Gene Expression

Guochun Liao, Jianmei Wang, Jingshu Guo, John Allard, Janet Cheng, Anh Ng, Steve Shafer, Anne Puech, John D. McPherson, Dorothee Foernzler, Gary Peltz, and Jonathan Usuka
Science 22 October 2004: 690-695.
Computational analysis of genetic maps can quickly identify the genes responsible for trait variation in 16 inbred mouse strains. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

The PP2A-Associated Protein 4 Is an Essential Inhibitor of Apoptosis

Mei Kong, Casey J. Fox, James Mu, Laura Solt, Anne Xu, Ryan M. Cinalli, Morris J. Birnbaum, Tullia Lindsten, and Craig B. Thompson
Science 22 October 2004: 695-698.
An inhibitory subunit of a phosphatase enzyme prevents it from activating the transcription factors that trigger suicide in mammalian cells. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

A Network of Control Mediated by Regulator of Calcium/Calmodulin-Dependent Signaling

S. V. Rakhilin, P. A. Olson, A. Nishi, N. N. Starkova, A. A. Fienberg, A. C. Nairn, D. J. Surmeier, and P. Greengard
Science 22 October 2004: 698-701.
A previously undescribed protein increases signals transmitted by neurons by amplifying two major signaling pathways. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Plant Cuticular Lipid Export Requires an ABC Transporter

Jamie A. Pighin, Huanquan Zheng, Laura J. Balakshin, Ian P. Goodman, Tamara L. Western, Reinhard Jetter, Ljerka Kunst, and A. Lacey Samuels
Science 22 October 2004: 702-704.
The waxy coating on the leaves of plants is deposited by lipid transporters similar to those found in mammals. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Oscillations in NF-B Signaling Control the Dynamics of Gene Expression

D. E. Nelson, A. E. C. Ihekwaba, M. Elliott, J. R. Johnson, C. A. Gibney, B. E. Foreman, G. Nelson, V. See, C. A. Horton, D. G. Spiller, S. W. Edwards, H. P. McDowell, J. F. Unitt, E. Sullivan, R. Grimley, N. Benson, D. Broomhead, D. B. Kell, and M. R. H. White
Science 22 October 2004: 704-708.
Nuclear-cytoplasmic oscillations of a transcription factor are required for sustained gene expression in response to a stimulus. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Technical Comments

 Comment on "Bedout: A Possible End-Permian Impact Crater Offshore of Northwestern Australia"

Andrew Glikson
Science 22 October 2004: 613.
Full Text »|   PDF »|  

 Response to Comment on "Bedout: A Possible End-Permian Impact Crater Offshore of Northwestern Australia"

L. Becker, R. J. Poreda, A. R. Basu, K. O. Pope, T. M. Harrison, C. Nicholson, and R. Iasky
Science 22 October 2004: 613.
Full Text »|   PDF »|