COVER Autophagy, in which cells degrade their own organelles and proteins to reuse the constituents, is important for normal human physiology. Cells form a double-membrane vesicle (blue) that sequesters cytosol and organelles (red oblong). The resulting autophagosome fuses with the lysosome (green sphere), allowing the cargo to be broken down and reused. See page 990. [Image: design by D. J. Klionsky and B. A. Rafferty, 3D modeling and rendering by B. A. Rafferty]

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