Cell Signaling

Common Signaling Themes

L. Bryan Ray, Elizabeth M. Adler, and Nancy R. Gough
Science 26 November 2004: 1505.
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Viewpoints

Common and Distinct Elements in Cellular Signaling via EGF and FGF Receptors

Joseph Schlessinger
Science 26 November 2004: 1506-1507.
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Pheromone Signaling Mechanisms in Yeast: A Prototypical Sex Machine

Yuqi Wang and Henrik G. Dohlman
Science 26 November 2004: 1508-1509.
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Jekyll and Hyde in the Microbial World

Dagmar M. Truckses, Lindsay S. Garrenton, and Jeremy Thorner
Science 26 November 2004: 1509-1511.
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When the Stress of Your Environment Makes You Go HOG Wild

Patrick J. Westfall, Daniel R. Ballon, and Jeremy Thorner
Science 26 November 2004: 1511-1512.
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The Ethylene Signaling Pathway

Jose M. Alonso and Anna N. Stepanova
Science 26 November 2004: 1513-1515.
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Keeping the Leaves Green Above Us

Aurélie Gfeller and Edward E. Farmer
Science 26 November 2004: 1515-1516.
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Natural Killer Cell Signaling Pathways

Eric Vivier, Jacques A. Nunès, and Frédéric Vély
Science 26 November 2004: 1517-1519.
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This Week in Science

Editor summaries of this week's papers.
Science 26 November 2004: 1433.
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Editorial:
A Two-Way Bioinformatic Street

Lee E. Eiden
Science 26 November 2004: 1437.
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Editors' Choice

Highlights of the recent literature.
Science 26 November 2004: 1439.
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NetWatch

Best of the Web in science.
Science 26 November 2004: 1449.
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  AAAS News & Notes

Science 26 November 2004: 1496-1497.

 New Products

Science 26 November 2004: 1579.
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News of the Week

U.S. NATIONAL ACADEMIES:
Advice on Science Advising Leaves Plenty of Questions

Jeffrey Mervis
Science 26 November 2004: 1450-1451.
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PALEOANTHROPOLOGY:
Skeptic to Take Possession of Flores Hominid Bones

Michael Balter
Science 26 November 2004: 1450.
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SCHOLARLY PUBLISHING:
NIH Flooded With Comments on Public Access Proposal

Jocelyn Kaiser
Science 26 November 2004: 1451.
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OBESITY RESEARCH:
New Data on Appetite-Suppressing Peptide Challenge Critics

Trisha Gura
Science 26 November 2004: 1453-1454.
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EVOLUTION:
Ice Ages May Explain Ancient Bison's Boom-Bust History

Elizabeth Pennisi
Science 26 November 2004: 1454.
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MEDICINE:
Bone Marrow Cells: The Source of Gastric Cancer?

Jean Marx
Science 26 November 2004: 1455-1457.
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BIOCHEMISTRY:
Immune Cells Speed the Evolution of Novel Proteins

Robert F. Service
Science 26 November 2004: 1457.
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AGRICULTURE:
China Could Be First Nation to Approve Sale of GM Rice

Xiong Lei
Science 26 November 2004: 1458-1459.
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PARTICLE PHYSICS:
Neutrinos Are All Flip-Floppers, Japanese Study Shows

Charles Seife
Science 26 November 2004: 1458.
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EUROPEAN SCIENCE:
New Commissioner Calls for Evolution, Not Revolution

Gretchen Vogel
Science 26 November 2004: 1459.
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ScienceScope

Science 26 November 2004: 1453.
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Random Samples

Science 26 November 2004: 1469.
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News Focus

THEORETICAL PHYSICS:
String Theory Gets Real--Sort Of

Adrian Cho
Science 26 November 2004: 1460-1462.
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THEORETICAL PHYSICS:
The Children of the Revolution

Adrian Cho
Science 26 November 2004: 1461.
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U.S. SCIENCE POLICY:
What Can NIH Do for Physicists?

Jeffrey Mervis
Science 26 November 2004: 1463.
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MIDDLE EAST:
X-ray Source Produces a Glimmer of Hope

Gretchen Vogel
Science 26 November 2004: 1465.
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SOCIETY OF VERTEBRATE PALEONTOLOGY MEETING:
Head Games Show Whether Dinos Went on Two Legs or Four

Erik Stokstad
Science 26 November 2004: 1466.
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SOCIETY OF VERTEBRATE PALEONTOLOGY MEETING:
Antiextinction Tip: Eat to Live

Erik Stokstad
Science 26 November 2004: 1466-1467.
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SOCIETY OF VERTEBRATE PALEONTOLOGY MEETING:
Timing Complicates History of Horses

Erik Stokstad
Science 26 November 2004: 1467.
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SOCIETY OF VERTEBRATE PALEONTOLOGY MEETING:
Snapshots From the Meeting

Erik Stokstad
Science 26 November 2004: 1467.
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Letters

This Week's Letters

Science 26 November 2004: 1473.
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 Using Stimulants in Children with ADHD

Daniel A. Waschbusch and William E. Pelham, Jr.
Science 26 November 2004: 1473.
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 Outbreak of West Nile Virus in North America

A. Spielman, T. G. Andreadis, C. S. Apperson, A. J. Cornel, J. F. Day, J. D. Edman, D. Fish, L. C. Harrington, A. E. Kiszewski, R. Lampman, G. C. Lanzaro, F.-R. Matuschka, L. E. Munstermann, R. S. Nasci, D. E. Norris, R. J. Novak, R. J. Pollack, W. K. Reisen, P. Reiter, H. M. Savage, W. J. Tabachnick, D. M Wesson;, Dina M. Fonseca, Nusha Keyghobadi, Colin A. Malcolm, Francis Schaffner, Motoyoshi Mogi, Robert C. Fleischer, and Richard C. Wilkerson
Science 26 November 2004: 1473-1475.
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 Mouse Biology at Monterotondo

Fotis C. Kafatos
Science 26 November 2004: 1475.
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 Beauty, Art, and Foreplay?

Martin Grayson
Science 26 November 2004: 1477.
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 CORRECTIONS AND CLARIFICATIONS

Science 26 November 2004: 1477.
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Books et al.

PRACTICE OF SCIENCE:
Weighing the Evidence

Marc Mangel
Science 26 November 2004: 1478.
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ENVIRONMENT:
What's Been Going On in the Woods

Michael Williams
Science 26 November 2004: 1479-1480.
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EXHIBITS:
Nota Bene: Tricking Our Vision

Julia Fahrenkamp-Uppenbrink
Science 26 November 2004: 1480.
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 Books Received

Science 26 November 2004: 1480.

Policy Forum

SOCIAL PSYCHOLOGY:
Why Ordinary People Torture Enemy Prisoners

Susan T. Fiske, Lasana T. Harris, and Amy J. C. Cuddy
Science 26 November 2004: 1482-1483.
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Perspectives

MOLECULAR BIOLOGY:
A Higher Order of Silence

Adone Mohd-Sarip and C. Peter Verrijzer
Science 26 November 2004: 1484-1485.
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PHYSICS:
What Is Dark Matter Made Of?

Konstantin Zioutas, Dieter H. H. Hoffmann, Konrad Dennerl, and Thomas Papaevangelou
Science 26 November 2004: 1485-1488.
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ECOLOGY:
Enhanced: Oh the Locusts Sang, Then They Dropped Dead

Richard S. Ostfeld and Felicia Keesing
Science 26 November 2004: 1488-1489.
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PLANETARY SCIENCE:
Nothing Simple About Asteroids

Erik Asphaug
Science 26 November 2004: 1489-1492.
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EVOLUTION:
Epistasis in RNA Viruses

Yannis Michalakis and Denis Roze
Science 26 November 2004: 1492-1493.
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Brevia

Stokes Drag on a Sphere in a Nematic Liquid Crystal

J. C. Loudet, P. Hanusse, and P. Poulin
Science 26 November 2004: 1525.
Measurement of the Brownian motion of droplets in an anisotropic liquid confirms the theoretical predictions of how drag varies in different directions. Abstract »|   Full Text »|   PDF »|  

Reports

Impact-Induced Seismic Activity on Asteroid 433 Eros: A Surface Modification Process

James E. Richardson, H. Jay Melosh, and Richard Greenberg
Science 26 November 2004: 1526-1529.
Impact-induced seismic reverberations on the asteroid Eros, despite its low gravity, cause its loose soil to accumulate in craters covering some small craters completely. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Periodic Mesoporous Dendrisilicas

Kai Landskron and Geoffrey A. Ozin
Science 26 November 2004: 1529-1532.
Branched organic molecules and siloxy groups can self-assemble to yield a material with large linear pores surrounded by porous walls that can transmit fluids or act as a sieve. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

A Reversible Synthetic Rotary Molecular Motor

José V. Hernández, Euan R. Kay, and David A. Leigh
Science 26 November 2004: 1532-1537.
Chemical reactions can drive a small molecular ring sequentially around a larger ring in either direction. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Three-Dimensional Hydrogen Microscopy in Diamond

P. Reichart, G. Datzmann, A. Hauptner, R. Hertenberger, C. Wild, and G. Dollinger
Science 26 November 2004: 1537-1540.
Proton-proton scattering reveals hydrogen impurities in artificial diamonds, providing critical information for improving their synthesis and material properties. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Probing Electronic Transitions in Individual Carbon Nanotubes by Rayleigh Scattering

Matthew Y. Sfeir, Feng Wang, Limin Huang, Chia-Chin Chuang, J. Hone, Stephen P. O'Brien, Tony F. Heinz, and Louis E. Brus
Science 26 November 2004: 1540-1543.
Published online 28 October 2004 [DOI: 10.1126/science.1103294] (in Science Express Reports)
Semiconducting and metallic nanotubes can be distinguished by how they scatter a bright white light. Abstract »|   Full Text »|   PDF »|  

Seismic Anisotropy Beneath Ruapehu Volcano: A Possible Eruption Forecasting Tool

Alexander Gerst and Martha K. Savage
Science 26 November 2004: 1543-1547.
Magma ascent likely altered the distribution of cracks beneath a New Zealand volcano over several years, affecting the speed of seismic waves traveling in different directions. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Evidence for Positive Epistasis in HIV-1

Sebastian Bonhoeffer, Colombe Chappey, Neil T. Parkin, Jeanette M. Whitcomb, and Christos J. Petropoulos
Science 26 November 2004: 1547-1550.
The effect of multiple mutations on the growth of HIV is less than expected from the sum of their individual effects, contradicting current genetic theories of sexual reproduction. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Femtomolar Sensitivity of a NO Sensor from Clostridium botulinum

Pierre Nioche, Vladimir Berka, Julia Vipond, Nigel Minton, Ah-Lim Tsai, and C. S. Raman
Science 26 November 2004: 1550-1553.
Published online 7 October 2004 [DOI: 10.1126/science.1103596] (in Science Express Reports)
Prokaryotes contain an ancient protein with an unusual heme-nitrosyl complex that strongly binds and sequesters the otherwise deadly signaling molecule nitric oxide. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Compensated Deleterious Mutations in Insect Genomes

Rob J. Kulathinal, Brian R. Bettencourt, and Daniel L. Hartl
Science 26 November 2004: 1553-1554.
Published online 21 October 2004 [DOI: 10.1126/science.1100522] (in Science Express Reports)
During the evolution of Drosophila, genetic mutations commonly canceled out the effects of other, harmful mutations. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

A Probabilistic Functional Network of Yeast Genes

Insuk Lee, Shailesh V. Date, Alex T. Adai, and Edward M. Marcotte
Science 26 November 2004: 1555-1558.
Bayesian combination of connections from protein interaction and microarray studies in yeast yields a gene interaction map that is more robust than that produced by only one approach. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Requirement of JNK2 for Scavenger Receptor A-Mediated Foam Cell Formation in Atherogenesis

Romeo Ricci, Grzegorz Sumara, Izabela Sumara, Izabela Rozenberg, Michael Kurrer, Alexander Akhmedov, Martin Hersberger, Urs Eriksson, Franz R. Eberli, Burkhard Becher, Jan Borén, Mian Chen, Myron I. Cybulsky, Kathryn J. Moore, Mason W. Freeman, Erwin F. Wagner, Christian M. Matter, and Thomas F. Lüscher
Science 26 November 2004: 1558-1561.
Inhibition of a stress-related kinase can help to prevent atherosclerosis in a mouse model of the disease. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Rise and Fall of the Beringian Steppe Bison

Beth Shapiro, Alexei J. Drummond, Andrew Rambaut, Michael C. Wilson, Paul E. Matheus, Andrei V. Sher, Oliver G. Pybus, M. Thomas P. Gilbert, Ian Barnes, Jonas Binladen, Eske Willerslev, Anders J. Hansen, Gennady F. Baryshnikov, James A. Burns, Sergei Davydov, Jonathan C. Driver, Duane G. Froese, C. Richard Harington, Grant Keddie, Pavel Kosintsev, Michael L. Kunz, Larry D. Martin, Robert O. Stephenson, John Storer, Richard Tedford, Sergei Zimov, and Alan Cooper
Science 26 November 2004: 1561-1565.
A sharp decline in the genetic diversity of fossil bison in Eastern Siberia and North America began about 35,000 years ago, when glaciers were advancing, not later when human hunting peaked. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Periodical Cicadas as Resource Pulses in North American Forests

Louie H. Yang
Science 26 November 2004: 1565-1567.
Experimental treatments imply that the numerous cicada carcasses that litter forest floors every 17 years fertilize the forest ecosystem, first below ground, then above. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Gastric Cancer Originating from Bone Marrow-Derived Cells

JeanMarie Houghton, Calin Stoicov, Sachiyo Nomura, Arlin B. Rogers, Jane Carlson, Hanchen Li, Xun Cai, James G. Fox, James R. Goldenring, and Timothy C. Wang
Science 26 November 2004: 1568-1571.
The stem cells that give rise to gastric cancer in mice are derived from bone marrow, not from the local epithelia as previously assumed. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Nucleosome Arrays Reveal the Two-Start Organization of the Chromatin Fiber

Benedetta Dorigo, Thomas Schalch, Alexandra Kulangara, Sylwia Duda, Rasmus R. Schroeder, and Timothy J. Richmond
Science 26 November 2004: 1571-1573.
The 30-nanometer-wide fiber of chromatin is formed by two side-by-side helices of nucleosomes, not a single helix as suggested by the classical solenoid model. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Chromatin Compaction by a Polycomb Group Protein Complex

Nicole J. Francis, Robert E. Kingston, and Christopher L. Woodcock
Science 26 November 2004: 1574-1577.
A development protein silences chromatin by inducing the nucleosomes to cluster. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Technical Comments

 Comment on "Enhanced Open Ocean Storage of CO₂ from Shelf Sea Pumping"

Wei-Jun Cai and Minhan Dai
Science 26 November 2004: 1477.
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 Response to Comment on "Enhanced Open Ocean Storage of CO₂ from Shelf Sea Pumping"

Helmuth Thomas, Yann Bozec, Khalid Elkalay, and Hein J. W. de Baar
Science 26 November 2004: 1477.
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